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MTP3 is specifically localized to the vacuolar membrane for Cd compartmentalization 23 Natural resistance-associated macrophage proteins (NRAMPs) enabling long-distance transport through symplastic loading, particularly NRAMP1 and NRAMP5 mediated root-to-shoot translocation

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Conclusive remarks Ongoing research in MS therapeutics seeks strategies to target or modulate the pro-inflammatory responses into a more anti-inflammatory scenario, in which antigen-specific immune tolerance may be induced and, in this regard, manipulating B reg subsets may be successful